中文I-New Coronavirus Variant Strain 501Y-V2 yaseNingizimu Afrika
NgoDisemba 18, 2020, iNingizimu Afrika yathola ukuguqulwa kwe-501Y-V2 ye-coronavirus entsha.Manje inguquko yaseNingizimu Afrika isisabalele emazweni angaphezu kuka-20.Ukuhlola kubonise ukuthi ngaphezu kwe-New Corona-virus Mutants ingase iphathe ezinye izinhlobo ze-New Coronavirus ezishintshashintshayo ze-K417N/T, E484K kanye ne-N501Y ezinganciphisa amandla okunciphisa amandla amasosha omzimba abangelwa umgomo we-plasma.Nokho, uma kuqhathaniswa ne-reference genome i-Wuh01 (inombolo yokulandelana engu-MN908947), i-501Y.V2 yokulandelana kwegenome eguquguqukayo yaseNingizimu Afrika inokuhlukahluka okungu-23 kwe-nucleotide.Inokuguqulwa okufanayo kwe-N501Y njengohlobo oluncane lwaseBrithani oluguquguqukayo lwe-B.1.1.7, kodwa isaqukethe ukuguqulwa kwezingosi ezimbili ezibalulekile i-E484K kanye ne-K417N ye-protein engu-S enemiphumela enamandla enamandla ekhonweni legciwane lokuthelela.
I-New Coronavirus iyi-RNA Virus ene-Single-stranded, ukuguqulwa kwe-Genome kuvame kakhulu.Ukutholwa kwethagethi eyodwa kungaholela kalula ekutholakaleni okugejiwe kwamasampuli anomthamo wegciwane egazini kanye nezinhlobo zegciwane eziguquliwe.Izinga lokuhlolwa kabusha kokukodwa ekutholweni okuqondiwe, lingafinyelela ngaphezu kuka-10%, okungase kwandise umsebenzi futhi kwandise isikhathi sokuxilongwa.Ukutholwa okuhlosiwe okuningi nokuqinisekisa okufanayo kwemiphumela yethagethi ngayinye kungakhuphula izinga lokutholwa futhi kusize ukuxilonga kusenesikhathi.
Umfanekiso 1. Umdwebo wohlelo lwendlela yokutheleleka nge-New Coronavirus
I-New Coronavirus Mutant B.1.1.7 yaseBrithani
Ngomhla zingama-26 kuZibandlela, 2020, iphepha lokuqala lesayensi le-B.1.1.7 Strain lashicilelwa ku-inthanethi.I-Institute of Hygiene University of London UK and Tropical Diseases, iqinisekise ukuthi i-B.1.1.7 Strain iyakwazi ukusabalala kunezinye izinhlobo, okwakungaphezu kuka-56% (95% CI 50-74%).Ngenxa yokuthi lolu hlobo olusha lwe-mutant lunamandla okudlulisela asobala, sekunzima kakhulu ukulawula i-COVID-19.Ngosuku olulandelayo, iNyuvesi yaseBirmingham e-United Kingdom yafaka isihloko nge-MedRxiv.Ucwaningo lwathola ukuthi inani le-ORF1ab kanye ne-N virus gene copy ezigulini ezitheleleke nge-B.1.1.7 mutant strain (S-gene dropout) landa kakhulu;lesi simo sagadwa emphakathini.Lesi sihloko sibonisa ukuthi iziguli ezingenwe i-mutant B.1.1.7 yaseBrithani zinenani legciwane egazini eliphakeme kakhulu, ngakho-ke le mutant ingase ibe ne-pathogenic eyengeziwe.
Umfanekiso 2. Ukulandelana kokuguqulwa kofuzo okuqukethwe kuhlobo lwe-coronavirus mutant B.1.1.7 yaseBrithani
Umfanekiso 3. Ukuguqulwa kwe-N501Y kwenzeke eBrithani naseNingizimu AfrikaOkuhlukile
Ikhithi Yokuthola Izinhlobo Ezintsha ZeCoronavirus
I-Chuangkun Biotech Inc. ithuthukise ngempumelelo ikhithi yokuthola ye-B.1.1.7 kanye ne-501Y-V2 ehlukile ye-coronavirus entsha.
Ubuhle balo mkhiqizo: ukuzwela okuphezulu, ukutholwa kanyekanye kokuhlosiwe okungu-4, okuhlanganisa amasayithi amakhulu okuguqulwa kwe-B.1.1.7 uhlobo oluguquguqukayo lwe-B.1.1.7 kanye ne-501Y.V2 yaseNingizimu Afrika yohlobo lwe-mutant.Le khithi ingathola ngasikhathi sinye i-N501Y, HV69-70del, E484K amasayithi okuguqula kanye nofuzo olusha lwe-coronavirus S;Ukuhlola okusheshayo: kuthatha ihora elingu-1 kuphela amaminithi angu-30 kusukela ekuqoqweni kwesampula kuya kumphumela.
Umfanekiso 4. Ukutholwa kwe-COVID-19 Britain Variant Amplification Curve
Umfanekiso 5. Ukutholwa kwe-COVID-19 South African Variant Amplification Curve
Umfanekiso 6. Uhlobo lwasendle lwejika le-New coronavirus amplification
Akukacaci ukuthi lezi zinguquko ziwuqongelela kanjani umthelela omusha wesikhathi eside wobhubhane lwe-COVID-19 ilungelo.Kodwa lokhu kusikhumbuza ukuthi lezi zinguquko zingase zibe nomthelela ekusebenzeni kokuzivikela kwemvelo nokugoma okulethwa ukugoma.Kusikhumbuza futhi ukuthi sidinga ukuqhubeka siqaphe i-coronavirus entsha isikhathi eside futhi sibuyekeze umuthi wokugomela i-COVID-19 ukuze sibhekane nokuvela kwe-coronavirus entsha.
Isikhathi sokuthumela: Mar-12-2021