I-CHKBiotech yathuthukisa ngempumelelo ikhithi yokuthola yezinhlobonhlobo ezintsha ze-coronavirus

Uhlobo olusha lweCoronavirus Variant 501Y-V2 yaseNingizimu Afrika
NgoDisemba 18, 2020, iNingizimu Afrika yathola i-501Y-V2 mutant ye-coronavirus entsha. Manje i-mutant yaseNingizimu Afrika isabalale emazweni angaphezu kwama-20. Ucwaningo lukhombisile ukuthi ngaphezu kweNew Corona-virus Mutants ingahle ithwale ezinye izinhlobo ezintsha ze-K417N / T, E484K kanye ne-N501Y ezinganciphisa amandla okuqeda amandla omuthi wokuvikela omzimba owenziwe ngeplasma. Kodwa-ke, uma kuqhathaniswa ne-reference genome Wuh01 (inombolo yokulandelana kwe-MN908947), i-501Y.V2 yokulandelana kwe-genome yaseNingizimu Afrika inezinhlobo ezingama-23 ze-nucleotide. Inokushintshwa okufanayo kwe-N501Y njenge-mutant Britain B.1.1.7 sub-type, kepha isaphethe ukuguquka kwezakhi zofuzo ezindaweni ezimbili ezisemqoka i-E484K ne-K417N ye-S protein ezinemiphumela engaba namandla emandleni okutheleleka ngegciwane.

I-New Coronavirus iyi-RNA Virus enezintambo ezi-Single, okushintsha kakhulu kweGenome. Ukutholwa kwelitshe elilodwa kungaholela ekutholeni amasampuli angabibikho anesisindo esiphansi segciwane kanye namagciwane aguqukile. Izinga lokuhlolwa kabusha kokutholile okukodwa ekutholeni okuqondiwe, lingafinyelela ngaphezu kwe-10%, elingakhuphula umthwalo womsebenzi futhi landise isikhathi sokuxilongwa. Ukutholwa kwamatshe amaningi nokuqinisekiswa kokuhlangana kwemiphumela yethagethi ngayinye kungakhuphula izinga lokutholwa futhi kukhuthaze ukuxilongwa ngaphambi kwesikhathi.

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Umdwebo 1. Umdwebo wesikimu wendlela yokutheleleka ye-New Coronavirus

ICoronavirus Mutant B.1.1.7 yaseBrithani entsha
NgoDisemba 26th, 2020, iphepha lokuqala lesayensi le-B.1.1.7 Strain lashicilelwa ku-inthanethi. I-Institute of Hygiene University of London UK and Tropical Diseases, ikuqinisekisile ukuthi i-B.1.1.7 Strain ikwazi ukusabalala ukwedlula ezinye izinhlobo, ebezingaphezulu kuka-56% (95% CI 50-74%). Ngoba lolu hlobo olusha lwe-mutant lunamandla wokudlulisa asobala ngokwengeziwe, kube nzima kakhulu ukulawula i-COVID-19. Ngakusasa, i-University of Birmingham e-United Kingdom ilayishe i-athikili nge-MedRxiv. Ucwaningo luthole ukuthi inani lama-ORF1ab kanye nama-virus egciwane angama-N amakhophi eziguli ezitheleleke nge-B.1.1.7 mutant strain (S-gene dropout) lenyuswe kakhulu; lo mkhuba waqashwa kubantu. Lo mbhalo uveza ukuthi iziguli ezitheleleke nge-mutant B.1.1.7 yaseBrithani zinomthamo wegciwane ophakeme kakhulu, ngakho-ke le mutant nayo ingaba ne-pathogenic ethe xaxa.

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Umdwebo 2. Ukulandelana kokuguqulwa kwezakhi zofuzo kuqukethe uhlobo lwe-coronavirus mutant B.1.1.7 yaseBrithani

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Umdwebo 3. Ukuguqulwa kwezinguquko kwe-N501Y kwenzeke eBrithani naseNingizimu Afrika Okuhlukile

Ukutholwa Kwezinto ezintsha ze-Coronavirus Variants
I-Chuangkun Biotech Inc. ithuthukise ngempumelelo ikhithi yokuthola ye-B.1.1.7 ne-501Y-V2 entsha ye-coronavirus.

Izinzuzo zalo mkhiqizo: ukuzwela okuphezulu, ukutholwa ngasikhathi sinye kwezinhloso ezi-4, ezihlanganisa izindawo eziyinhloko zokuguqula izakhi ze-B.1.1.7 ze-mutant kanye ne-501Y.V2 yaseNingizimu Afrika. Le kit ingathola ngasikhathi sinye amasayithi wokuguqula i-N501Y, HV69-70del, E484K nohlobo olusha lwe-coronavirus S; Ukuhlolwa okusheshayo: kuthatha kuphela ihora elingu-1 imizuzu engama-30 ukusuka ekuqoqweni kwesampula ukulandela.

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Umdwebo 4. Ukutholwa kwejika le-COVID-19 Britain Variant Amplification

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Umdwebo 5. Ukutholwa kwejika le-COVID-19 South African Variant Amplification Curve

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Umdwebo 6. Uhlobo lwasendle lwe-New coronavirus amplification curve

Akucaci ukuthi lezi zinguquko ziwuqongelela kanjani umthelela omusha wesikhathi eside wesifo se-COVID-19. Kepha lokhu kusikhumbuza ukuthi lokhu kuguquka kungathinta ukusebenza kokuvikeleka kwemvelo nokuvikeleka okulethwa ukugoma. Kusikhumbuza futhi ukuthi sidinga ukuqapha ngokuqhubekayo i-coronavirus entsha isikhathi eside futhi sibuyekeze umuthi wokugoma we-COVID-19 ukubhekana nokuvela kwe-coronavirus entsha.


Isikhathi sokuthumela: Mar-12-2021